The Power of Creatine Supplementation for Cognitive Function

Hand cradles glowing electric brain

Quick Look

  • Creatine is a naturally occurring compound primarily found in muscle cells, which plays a crucial role in producing adenosine triphosphate (ATP), the energy currency of cells. 
  • Creatine supports the brain’s energy needs, aiding in its overall function. 

Many people are looking into different supplements to stay healthy, and one interesting option that’s getting popular is creatine. It’s not just used to strengthen your body; it helps your brain work better. This blog will explore: Can creatine make my brain work better? How does creatine affect how we think? And could it be a good solution for problems like ADHD and brain fog?

Understanding Creatine and Its Cognitive Benefits

Creatine is a natural compound found in our bodies, primarily in skeletal muscle, but it also plays a vital role in various bodily functions. It’s made up of amino acids and helps produce a molecule called adenosine triphosphate (ATP), essential for providing quick bursts of energy to our cells. While our bodies produce creatine independently, it’s also found in certain foods like meat and fish. 

Many athletes and fitness enthusiasts use creatine supplements to enhance their physical performance, as creatine helps muscles produce energy during intense activities like weightlifting or sprinting. Beyond its role in muscle function, research is uncovering potential cognitive and mental health benefits of creatine. In essence, creatine is a fascinating compound that serves multiple functions in supporting both our physical and mental well-being.

Exploring cognitive gains

Creatine Supplementation for Cognitive Function

Despite comprising a small percentage of the body weight, the brain is a metabolically demanding organ. It requires significant energy to support various cognitive functions, including memory, attention, and executive function. 

Creatine does more than just boost our physical performance – it also plays a crucial role in helping our brains function well. It produces a compound called ATP, which acts as energy currency in our bodies. ATP is crucial for neurotransmitter synthesis, synaptic function, and overall neuron activity. By supporting these processes, creatine may positively impact cognitive abilities.

Research has shown that creatine supplementation may enhance cognitive performance by improving ATP availability in the brain. 

The Role of Creatine in Supporting Brain Energy and Function

The creatine pool in the human brain refers to the presence and dynamic regulation of creatine within the central nervous system. Creatine, a natural compound produced in the body and obtained through certain foods, plays a crucial role in the brain’s energy metabolism. 

The brain maintains a creatine pool to ensure a steady energy supply for various cognitive functions. This reservoir of creatine supports the production of ATP. 

Researchers are increasingly exploring the intricate mechanisms of the creatine pool in the brain, seeking to understand how its regulation influences cognitive performance and whether manipulating this pool can have therapeutic implications for conditions affecting brain health.

Effects of Creatine Supplementation on Cognition of Healthy Individuals

Scientists have looked at how creatine supplements might help our brains work better. They’ve looked at these studies very carefully to understand the potential benefits of creatine for our thinking abilities. The research involves observing how creatine affects executive function (like making decisions), attention, and response inhibition (which means controlling impulsive actions). 

Although larger studies are needed, the exciting news is that scientists found positive outcomes after analyzing all this information. Creatine supplements positively impact these important aspects of thinking, hinting at the possibility that they might help make our minds work better overall. So, it’s not just about getting stronger; creatine could also be like a brain boost for us!

Creatine and Brain Fog

Many people struggle with “brain fog,” also known as mental fatigue. This condition makes people feel confused, forgetful, and not very clear-headed, and it can affect how we go about our daily lives. Some people wonder if taking creatine supplements could make brain fog better or worse.

Studies show that creatine supplements don’t worsen brain fog. Evidence suggests that creatine helps reduce mental fatigue and clears the mind, possibly improving memory in older adults. 

The connection between creatine and brain fog is quite complex. Creatine does a good job of supporting the production of ATP, which is like energy for our brains. By helping keep the brain’s energy levels up, creatine might lower the chances of feeling mentally tired and dealing with brain fog symptoms. Of course, everyone is different, and it’s important to talk to a healthcare professional before deciding to use creatine supplements to make sure it’s the right choice for you.

Creatine for ADHD and Improving Focus 

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent patterns of inattention, hyperactivity, and impulsivity. Managing ADHD often involves a combination of behavioral interventions and, in some cases, medication. The potential role of creatine in improving focus and attention in individuals with ADHD has become a subject of interest.

Researchers are currently exploring the link between creatine supplementation and ADHD. While the exact mechanisms are not fully understood, creatine’s impact on ATP availability and energy metabolism in the brain contributes to helping improve cognitive function in individuals with ADHD.

Brain lifting dumbbell

Beyond Muscles and Into Brain Health and Mental Well-being

Creatine supplementation can extend its benefits to other groups of people beyond athletes and muscle-building enthusiasts. Creatine’s potential cognitive benefits are of interest to those focused on healthy aging and even Alzheimer’s prevention. 

Creatine might play a role in supporting brain health and aiding memory and cognitive function. Additionally, aging individuals may find creatine helpful in maintaining muscle mass and strength, contributing to overall physical well-being.

Moreover, there is emerging interest in the relationship between creatine and mental health. Some studies indicate that creatine supplementation may have positive effects on conditions like depression and anxiety. While the exact mechanisms are still being explored, creatine’s impact on brain energy metabolism and neurotransmitter function may contribute to its potential mood-enhancing properties.

Anxiety, PTSD, and depression often go hand in hand with metabolic dysfunction and low energy levels in the brain. Creatine, known for its role in improving energy metabolism, becomes a promising candidate for offering benefits in managing these mental health conditions. Studies consistently show that people with lower creatine levels are more likely to experience depressive symptoms. Early trials where people took creatine as a supplement have shown some encouraging results, with small to moderate improvements in symptoms for those dealing with anxiety, PTSD, and depression. While more research is needed to understand the extent of these benefits fully, the connection between creatine and mental health suggests a potential avenue for support in managing these challenging conditions.

It’s important to approach creatine supplementation cautiously, especially when considering specific health concerns. Consulting with healthcare professionals is crucial, particularly for those at risk for Alzheimer’s or dealing with mental health conditions, to ensure that creatine supplementation aligns with their overall health goals and medical considerations.

Creatine and Sleep Deprivation 

While creatine is primarily known for its role in energy production and muscle function, limited evidence suggests that it might be relevant to sleep deprivation. Sleep deprivation can impact various physiological processes, including energy metabolism.

Some studies have explored the effects of creatine on sleep-deprived individuals, suggesting that creatine supplementation may mitigate certain aspects of cognitive decline associated with lack of sleep. Creatine’s role in supporting ATP production, the energy currency of cells, might contribute to maintaining cognitive performance during sleep deprivation.

However, it’s important to note that research in this area is still in the early stages, and more comprehensive studies are needed to establish a clear link between creatine supplementation and sleep deprivation. Additionally, individual responses to creatine can vary, and consulting with healthcare professionals before incorporating creatine supplements, especially during sleep-deprived periods, is advisable to ensure safety and suitability based on individual health conditions.

Who Benefits From Creatine Supplementation the Most?

Research findings from creatine reviews suggest that creatine supplementation may benefit individuals undergoing acute or chronic stress more. Additionally, those who typically consume smaller amounts of creatine through their diets, such as vegans and vegetarians, might find supplementation particularly advantageous. 

In times of stress, the body’s demand for energy increases, and creatine plays a crucial role in providing rapid energy to cells. Supplementation could bridge this gap for individuals with limited dietary sources of creatine, potentially aiding in maintaining physical and mental well-being during challenging periods. While further research is needed to understand the extent of these benefits fully, the evidence points towards creatine supplementation as a potential support, especially for those with lower dietary creatine intake. As with any dietary change, it’s advisable to consult with healthcare professionals to ensure personalized recommendations and safe usage.

How Much Creatine Should I Take for Brain Function?

Determining the right amount of creatine for brain function can vary from person to person. Generally, experts suggest a daily dose of 3 to 5 grams for overall health and physical performance. However, the optimal dosage is still being studied when it comes specifically to enhancing brain function. It’s crucial to approach creatine supplementation cautiously and start with the lower end of the recommended range. 

Consulting with a healthcare professional or a registered dietitian is advisable to get personalized advice based on individual health conditions and needs. Remembering that more isn’t always better, and finding the right balance is key to reaping the potential cognitive benefits of creatine while ensuring overall well-being.

What Is the Best Creatine Supplement for Brain Function?

Finding the best creatine supplement for brain function depends on various factors, including personal preferences and health needs. Creatine monohydrate is the most researched and widely used form, showing effectiveness in physical performance and potential cognitive benefits. 

Creatine monohydrate supplementation is often considered a safe and cost-effective choice. Other forms like creatine hydrochloride and creatine nitrate exist but may not have as much scientific backing.

Additionally, creatine kinase, an enzyme associated with creatine metabolism, is part of this intricate process. Creatine kinase helps regulate the levels of creatine and ATP, contributing to our brain’s energy production efficiency. As researchers continue observing the potential cognitive benefits of creatine supplementation, the connection between creatine, ATP, and creatine kinase presents an exciting study area for understanding how we can boost our brain function. 

When selecting a creatine supplement, looking for products from reputable brands is crucial, ensuring they undergo third-party testing for quality and purity. Additionally, consulting with a healthcare professional or a registered dietitian can help tailor the choice to individual health conditions and goals, providing personalized guidance on the best creatine supplement for brain function.

Side Effects of Creatine

Uneasy woman holds stomach

Concerns about the mental side effects of creatine are common, but research suggests that, in general, creatine is safe for most people when used appropriately. Following recommended dosages and consulting with healthcare professionals is crucial, especially if pre-existing health conditions exist. 

Some users report minor side effects like stomach discomfort or muscle cramps, but these are typically rare and can often be addressed by adjusting the dosage or staying hydrated. Importantly, numerous studies have not found consistent evidence linking creatine to negative mental side effects. 

Why Do I Feel Weird After Taking Creatine?

Feeling strange after taking creatine is not uncommon, and it might be due to a few reasons. Some people experience stomach discomfort or bloating, especially when using creatine. Drinking plenty of water can reduce these feelings. Additionally, creatine draws water into the muscles, which can lead to slight weight gain. 

It’s essential to remember that these sensations are usually temporary and can go away as your body gets used to the supplement. However, if you continue to feel weird or experience any unusual symptoms, it’s crucial to talk to a healthcare professional to ensure that creatine is suitable for you and to rule out any underlying issues.

Nutrient-packed snacks next to 'Brain Food' on a chalkboard

Eat a Diet Rich in Creatine

  • Meat: Red meat like beef and pork are rich sources of creatine
  • Fish: Certain types of fish, such as salmon and tuna, are high in creatine
  • Poultry: Chicken and turkey also contain creatine, although in slightly lower amounts than red meat
  • Dairy: Milk and other dairy products provide a lot of creatine
  • Eggs: Both the yolk and the whites of eggs contain creatine
  • Wild game: Game meats, like venison, can be high in creatine
  • Vegetarian sources: Some vegetables like beets and spinach contain creatine
  • Creatine supplements: Creatine is available in supplement form


Creatine supplementation’s potential for enhancing cognitive functioning opens up exciting possibilities for individuals seeking ways to support their mental well-being. From its positive impact on executive function and attention to its potential role in addressing ADHD symptoms, creatine’s cognitive benefits are becoming increasingly evident.

While research is ongoing, the evidence suggests that creatine supplementation is a promising avenue for optimizing cognitive performance. However, individual responses may vary, and it’s crucial to consult with healthcare professionals before incorporating creatine into one’s routine, especially for individuals with pre-existing medical conditions.

Frequently Asked Questions

Can creatine make my brain work better?

Evidence suggests that creatine supplementation may enhance cognitive performance by improving ATP availability in the brain. ATP is crucial for neurotransmitter synthesis, synaptic function, and overall neuronal activity, contributing to improved cognitive abilities.

How does creatine affect how we think?

Creatine positively influences executive function, attention, and response inhibition, as observed in various studies. It supports cognitive domains, potentially enhancing mental performance.

Could creatine be a good solution for problems like ADHD and brain fog?

Preliminary research indicates that creatine supplementation might have a positive impact on conditions like ADHD and brain fog. By supporting ATP production, creatine may help maintain optimal energy levels in the brain, reducing cognitive fatigue and associated symptoms.

Does creatine affect brain function?

Yes, creatine does affect brain function by contributing to energy metabolism. Its role in ATP production supports critical processes in the brain, potentially leading to improved cognitive function.

How much creatine should I take for the brain?

The optimal dosage for enhancing brain function is still under study. Generally, a daily dose of 3 to 5 grams is recommended for overall health, but individual responses may vary. It’s advisable to start with the lower end and consult healthcare professionals for personalized advice.

Does creatine remove brain fog?

Evidence suggests that creatine supplementation may help reduce cognitive fatigue and enhance mental clarity, potentially addressing symptoms associated with brain fog. However, individual responses vary, and consulting with healthcare professionals is recommended.

What brain disorders does creatine treat?

While research is ongoing, early studies show promise in using creatine for conditions like depression, anxiety, and potentially ADHD. However, it’s essential to note that creatine is not the sole treatment for brain disorders, and consultation with healthcare professionals is crucial for comprehensive management.


April Bruns | Registered Dietitian | ACE Personal Trainer

April Bruns | Registered Dietitian | ACE Personal Trainer

April is a registered dietitian and freelance health and wellness writer. She holds a BS in Food Science and Human Nutrition from Washington State University. She works as a private practice dietitian specializing in weight loss, gut health, and functional fitness.

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